Sharing an article from Science Daily, which I tend to do frequently. Curious about your thoughts? Do you want to restrict calories?

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ScienceDaily (2009-12-29) — Scientists searching for the secrets of how calorie-restricted diets increase longevity are reporting discovery of proteins in the fat cells of human volunteers that change as pounds drop off. The proteins could become markers for monitoring or boosting the effectiveness of calorie-restricted diets — the only scientifically proven way of extending life span in animals.